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VaxIQ/Shingrix (RZV)
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Shingrix (RZV)

Recombinant Zoster Vaccine (Shingrix)

Tier 1 · EPI/CoreVaccineCuration in progress

Platform: Adjuvanted recombinant subunit (AS01B)

Recombinant vaccine that prevents shingles (herpes zoster) and its complications in adults aged 50 and older.

shinglesAS01BgE antigenCD4 T cellolder adults

Immunology Sections

Curated section analysis in progress

Structured immunology sections — mechanism, immune response, molecular signatures, correlates of protection, and more — are being prepared by the Precision Vaccines Program team. In the meantime, verified references and live literature from PubMed, Semantic Scholar, and Wikipedia are available below.

MechanismImmune ResponseMolecular & Immune SignaturesCorrelates of ProtectionOpen QuestionsImmunogenicitySafetyInfection Immunology

Wikipedia Overview

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Zoster vaccine

A zoster vaccine is a vaccine that reduces the incidence of herpes zoster, a disease caused by reactivation of the varicella zoster virus, which is also responsible for chickenpox. Shingles provokes a painful rash with blisters and can be followed by chronic pain and other complications. Older people are more often affected, as are people with weakened immune systems (immunosuppression). Both shingles and postherpetic neuralgia can be prevented by vaccination.

PubMed Literature

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Semantic Scholar

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