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VaxIQ/Hantavirus (Experimental)
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Hantavirus (Experimental)

Hantavirus — HFRS and HPS (Experimental)

Tier 3 · ExperimentalPathogenCuration in progress

Platform: Pathogen — No Licensed Vaccine

Rodent-borne viral pathogen that causes hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) — no licensed vaccine available.

HFRSHPST cell pathogenesisPuumalaimmune paradox

EXPERIMENTAL — No licensed vaccine or therapeutic currently approved.

PubMed References

PMID 21436245Rasmuson. Activated airway T lymphocytes Puumala hantavirus. Chest 2011.
PMID 22085404Sadeghi. Cytokine expression acute Puumala hantavirus. BMC Immunol 2011.

Immunology Sections

Curated section analysis in progress

Structured immunology sections — mechanism, immune response, molecular signatures, correlates of protection, and more — are being prepared by the Precision Vaccines Program team. In the meantime, verified references and live literature from PubMed, Semantic Scholar, and Wikipedia are available below.

MechanismImmune ResponseMolecular & Immune SignaturesCorrelates of ProtectionOpen QuestionsImmunogenicitySafetyInfection Immunology

Verified References

PMID 21436245Rasmuson. Activated airway T lymphocytes Puumala hantavirus. Chest 2011.
PMID 22085404Sadeghi. Cytokine expression acute Puumala hantavirus. BMC Immunol 2011.

Wikipedia Overview

Full article ↗
Hantavirus

Orthohantavirus is a genus of viruses which includes all hantaviruses that cause disease in humans. Hantaviruses are naturally found primarily in rodents. In general, each hantavirus is carried by one rodent species and each rodent that carries a hantavirus carries one hantavirus species. Hantaviruses in their natural reservoirs usually cause an asymptomatic, persistent infection. In humans, however, hantaviruses cause two diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). HFRS is mainly caused by hantaviruses in Africa, Asia, and Europe, called Old World hantaviruses, and HPS is usually caused by hantaviruses in the Americas, called New World hantaviruses.

PubMed Literature

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Semantic Scholar

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