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VaxIQ/Ebola (rVSV-ZEBOV)
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Ebola (rVSV-ZEBOV)

Ebola Vaccine rVSV-ZEBOV (Ervebo)

Tier 1 · EPI/CoreVaccineCuration in progress

Platform: Recombinant vesicular stomatitis virus

Licensed vaccine that protects against Ebola virus disease, used in outbreak response through ring vaccination strategy.

Ebolaring vaccinationrVSVGP antibodylicensed

PubMed References

PMID 28017403Henao-Restrepo. rVSV-ZEBOV ring vaccination Guinea final results. Lancet 2016.
PMID 26248676Henao-Restrepo. rVSV-ZEBOV Guinea interim results. Lancet 2015.
PMID 28434944Dahlke. Dose-dependent T-cell dynamics rVSV-ZEBOV. EBioMedicine 2017.
PMID 27323685Farooq. Circulating Tfh cells rVSV-ZEBOV vaccine. Sci Rep 2016.

Immunology Sections

Curated section analysis in progress

Structured immunology sections — mechanism, immune response, molecular signatures, correlates of protection, and more — are being prepared by the Precision Vaccines Program team. In the meantime, verified references and live literature from PubMed, Semantic Scholar, and Wikipedia are available below.

MechanismImmune ResponseMolecular & Immune SignaturesCorrelates of ProtectionOpen QuestionsImmunogenicitySafetyInfection Immunology

Verified References

PMID 28017403Henao-Restrepo. rVSV-ZEBOV ring vaccination Guinea final results. Lancet 2016.
PMID 26248676Henao-Restrepo. rVSV-ZEBOV Guinea interim results. Lancet 2015.
PMID 28434944Dahlke. Dose-dependent T-cell dynamics rVSV-ZEBOV. EBioMedicine 2017.
PMID 27323685Farooq. Circulating Tfh cells rVSV-ZEBOV vaccine. Sci Rep 2016.

Wikipedia Overview

Full article ↗
Ebola vaccine

An Ebola vaccine is a vaccine used to prevent Ebola virus disease (Ebola). As of 2022, there are only two vaccines against the Zaire ebolavirus. The first vaccine to be approved in the United States is rVSV-ZEBOV in December 2019. It had been used extensively in the Kivu Ebola epidemic under a compassionate use protocol. During the early 21st century, several vaccine candidates displayed efficacy to protect nonhuman primates against lethal infection.

PubMed Literature

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Semantic Scholar

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