Cholera (Oral)
Oral Cholera Vaccine (Dukoral/Shanchol)
Platform: Killed whole-cell oral
Oral vaccine that protects against cholera, a severe acute diarrheal disease caused by Vibrio cholerae, used in endemic and outbreak settings.
Immunology Sections
Curated section analysis in progress
Structured immunology sections — mechanism, immune response, molecular signatures, correlates of protection, and more — are being prepared by the Precision Vaccines Program team. In the meantime, verified references and live literature from PubMed, Semantic Scholar, and Wikipedia are available below.
Wikipedia Overview
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A cholera vaccine is a vaccine that is effective at reducing the risk of contracting cholera. The recommended cholera vaccines are administered orally to elicit local immune responses in the gut, where the intestinal cells produce antibodies against Vibrio cholerae, the bacteria responsible for the illness. This immune response was poorly achieved with the injectable vaccines that were used until the 1970s. The first effective oral cholera vaccine was Dukoral, developed in Sweden in the 1980s. For the first six months after vaccination it provides about 85% protection, which decreases to approximately 60% during the first two years. When enough of the population is immunized, it may protect those who have not been immunized thereby increasing the total protective impact to more than 90 %.
PubMed Literature
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Semantic Scholar
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