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VaxIQ/BCG
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BCG

Bacille Calmette-Guérin

Tier 1 · EPI/CoreVaccineCuration in progress

Platform: Live attenuated bacterial

Vaccine against tuberculosis and a key tool for neonatal immunization in endemic regions.

trained immunitymetabolomicsneonataltuberculosisinnate

PubMed References

PMID 35508141Diray-Arce. BCG reprograms neonatal lipid metabolism. Cell Rep 2022.
PMID 27926861Arts/Netea. Immunometabolic pathways BCG trained immunity. Cell Rep 2016.
PMID 22988082Kleinnijenhuis/Netea. BCG NOD2 trained immunity. PNAS 2012.

Immunology Sections

Curated section analysis in progress

Structured immunology sections — mechanism, immune response, molecular signatures, correlates of protection, and more — are being prepared by the Precision Vaccines Program team. In the meantime, verified references and live literature from PubMed, Semantic Scholar, and Wikipedia are available below.

MechanismImmune ResponseMolecular & Immune SignaturesCorrelates of ProtectionOpen QuestionsImmunogenicitySafetyInfection Immunology

Verified References

PMID 35508141Diray-Arce. BCG reprograms neonatal lipid metabolism. Cell Rep 2022.
PMID 27926861Arts/Netea. Immunometabolic pathways BCG trained immunity. Cell Rep 2016.
PMID 22988082Kleinnijenhuis/Netea. BCG NOD2 trained immunity. PNAS 2012.

Wikipedia Overview

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BCG vaccine

The Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). It is named after its inventors Albert Calmette and Camille Guérin. In countries where tuberculosis or leprosy is common, one dose is recommended in healthy babies as soon after birth as possible. In areas where tuberculosis is not common, only children at high risk are typically immunized, while suspected cases of tuberculosis are individually tested for and treated. Adults who are frequently exposed to tuberculosis may also be immunized. BCG has some effectiveness against Buruli ulcer infection and other nontuberculous mycobacterial infections. It is also often used as part of the treatment of bladder cancer.

PubMed Literature

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Semantic Scholar

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